Bellus Health
Biopharmaceuticals
Working to treat chronic cough and other afferent hypersensitization-related disorders
BELLUS Health Inc. (Nasdaq: BLU; TSX: BLU) is a clinical stage biotechnology company focused on developing small molecules for the treatment of disorders that are characterized by hypersensitization. The company’s lead drug candidate BLU-5937 for chronic cough is a potent and highly selective oral inhibitor of the P2X3 receptor.
Headquarters: Quebec, Canada
Website: https://bellushealth.com/
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Cara Therapeutics
Biopharmaceuticals
A novel class of peripherally acting kappa opioid agonist therapeutics for treatment of pruritus
Cara Therapeutics, Inc. (Nasdaq: CARA) is a clinical-stage biopharmaceutical company focused on developing and commercializing new chemical entities designed to alleviate pruritus by selectively targeting peripheral kappa opioid receptors, or KORs. Cara’s pipeline of drugs is led by KORSUVA (CR845/difelikefalin), a first-in-class KOR agonist for treatment of pruritus in patients with chronic kidney disease.
Headquarters: Stamford, Connecticut
Website: https://www.caratherapeutics.com/
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Eidos Therapeutics
Biopharmaceuticals
Developing a novel therapeutic that addresses the root cause of Transthyretin (TTR) amyloidosis
Eidos Therapeutics, Inc. (NASDAQ: EIDX) is developing a novel drug to treat all forms of Transthyretin (TTR) amyloidosis, a condition characterized by toxic amyloid aggregates in the heart and peripheral nerves. The lead candidate, AG10 is an orally-administered, small molecule designed to mimic a naturally-occurring genetic rescue mutation that protects high-risk individuals from developing TTR amyloidosis.
Headquarters: San Francisco, California
Website: http://eidostx.com/
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Essential Medical
Medical Devices
A medical device company transforming the vascular closure market
Essential Medical is a medical technology company developing best-in-class vascular closure devices for femoral punctures following cardiac catheterization procedures. These procedures, such as TAVR and EVAR, are some of the fastest growing segments within interventional cardiology, highlighting the need for fast, easy and uncomplicated arterial closure solutions. The company was acquired by Teleflex (NYSE:TFX) in 2018.
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Impulse Dynamics
Medical Devices
A medical device company dedicated to transforming the treatment of chronic heart failure
Impulse Dynamics is a fast-growing medical device company that has pioneered a new form of therapy for heart failure called Cardiac Contractility Modulation, or CCM TM, which is delivered by the company’s Optimizer® Smart System. CCM is first-of-a-kind, FDA approved, life-changing treatment for a large population of heart failure patients with limited treatment options.
Headquarters: Mount Laurel, New Jersey
Website: https://impulse-dynamics.com/
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Inspire Medical Systems
Medical Devices
A manufacturer of the first fully implantable treatment for sleep apnea
Inspire Medical Systems, Inc. (NYSE: INSP) developed the world's first fully implantable neurostimulation system for treatment of obstructive sleep apnea. The device works by opening up the upper airway in synchrony with patient's breathing during sleep through gentle stimulation of the key airway muscles. It offers a safe, effective and minimally invasive alternative to millions of patients who have failed or are intolerant of Continuous Positive Airway Pressure (CPAP).
Headquarters: Maple Grove, Minnesota
Website: https://www.inspiresleep.com/
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Iterum Therapeutics
Biopharmaceuticals
A clinical-stage pharmaceutical company developing anti-infectives against multi-drug resistant(MDR)
Iterum Therapeutics plc (NASDAQ:ITRM) is dedicated to developing differentiated anti-infectives aimed at combatting multi-drug resistant pathogens to significantly improve the lives of people affected by serious and life-threatening diseases around the world. Iterum Therapeutics is advancing its first compound, sulopenem, a novel penem anti-infective compound with oral and IV formulations for the treatment of uncomplicated and complicated urinary tract infection and complicated intra-abdominal infection.
Headquarters: Dublin, Ireland
Website: http://www.iterumtx.com
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MEI Pharma
Biopharmaceuticals
An emerging pharmaceutical company focused on advancing new therapies for cancer
MEI Pharma, Inc. (NASDAQ: MEIP) is a San Diego-based oncology company focused on the clinical development of novel therapies for cancer. The company’s diverse portfolio of drug candidates includes Pracinostat, an oral HDAC inhibitor that is being developed in combination with azacitidine for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The clinical development pipeline also includes ME-401, a highly selective, oral PI3K delta inhibitor, voruciclib, an oral, selective CDK inhibitor, and ME-344, a novel mitochondrial inhibitor.
Headquarters: San Diego, California
Website: http://www.meipharma.com
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MIACH
Medical Devices
An emerging developer of bio-engineered implants for connective tissue injury
MIACH Orthopaedics, Inc. is a medical technology company developing innovative bio-engineered surgical implants for connective tissue repair. The company’s initial focus is on the Bridge-Enhanced® ACL Repair (BEAR®) technology as a viable high performance alternative to conventional ACL reconstruction using grafts. The BEAR technology was pioneered by Martha Murray, M.D., at the Boston Children’s Hospital Department of Orthopaedic Surgery.
Headquarters: Boston, Massachusetts
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Oyster Point Pharma
Biopharmaceuticals
First-in-class pharmaceutical therapies to treat ocular surface diseases
Oyster Point Pharma, Inc. (Nasdaq: OYST) is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization novel therapies to treat ocular surface diseases. Oyster Point Pharma’s lead product candidate, OC-01, a selective nicotinic acetylcholine receptor (nAChR) agonist, is being developed as a nasal spray to treat the signs and symptoms of dry eye disease. OC-01 works by restoring natural tear film production.
Headquarters: Princeton, New Jersey
Website: https://oysterpointrx.com/
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Selecta Biosciences, Inc.
Biopharmaceuticals
Unlocking the full potential of biologic therapies by avoiding unwanted immune responses
Selecta Biosciences, Inc. (NASDAQ: SELB) is a clinical-stage biopharmaceutical company focused on unlocking the full potential of biologic therapies by avoiding unwanted immune responses. Selecta is combining its tolerogenic Synthetic Vaccine Particles (SVP™) to a range of biologics for rare and serious diseases that require new treatment options. SEL-212, the company’s lead candidate is being developed to treat severe gout patients.
Headquarters: Watertown, Massachusetts
Website: http://selectabio.com/
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Shiratronics
Medical Devices
Developing an innovative neuromodulation therapy for severe migraine headaches
ShiraTronics, Inc. is an emerging medical device company developing an innovative neuromodulation approach to treat refractory migraine headaches.
Headquarters: Brooklyn Park, Minnesota
Website: https://shiratronics.com/
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